Drug interactions
Mycophenolate + Valganciclovir
Severity: Moderate
Mycophenolate and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolic acid glucuronide and ganciclovir compete for renal tubular secretion, so concentrations of both may rise, especially in renal impairment. Both drugs also cause myelosuppression, increasing the risk of neutropenia.
What this interaction means in plain words
Mycophenolate and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion plus additive bone marrow suppression.
What to do
Monitor complete blood counts regularly and adjust valganciclovir to renal function. Reduce doses or interrupt therapy if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valganciclovir
Frequently asked questions
Can I take Mycophenolate with Valganciclovir?
MediHelp rates the interaction as moderate. Mycophenolate and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolic acid glucuronide and ganciclovir compete for renal tubular secretion, so concentrations of both may rise, especially in renal impairment. Both drugs also cause myelosuppression, increasing the risk of neutropenia.
How serious is the interaction between Mycophenolate and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust valganciclovir to renal function. Reduce doses or interrupt therapy if neutropenia develops.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
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