Drug interactions
Mycophenolic acid + Norfloxacin
Severity: Moderate
Mycophenolic acid and Norfloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics that alter gut flora may reduce enterohepatic recirculation of mycophenolic acid, lowering exposure and potentially raising rejection risk. The effect is documented mainly for norfloxacin combined with metronidazole.
What this interaction means in plain words
Mycophenolic acid and Norfloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolic acid belongs to Miscellaneous; Norfloxacin belongs to Anti Bacterial.
Why it happens
Reduced gut bacterial deconjugation of MPA glucuronide decreases enterohepatic recycling.
What to do
Monitor for signs of reduced immunosuppression during antibiotic courses. Consider MPA exposure monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolic acid
Other interactions of Norfloxacin
Frequently asked questions
Can I take Mycophenolic acid with Norfloxacin?
MediHelp rates the interaction as moderate. Mycophenolic acid and Norfloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics that alter gut flora may reduce enterohepatic recirculation of mycophenolic acid, lowering exposure and potentially raising rejection risk. The effect is documented mainly for norfloxacin combined with metronidazole.
How serious is the interaction between Mycophenolic acid and Norfloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of reduced immunosuppression during antibiotic courses. Consider MPA exposure monitoring.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.
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