Drug interactions
Norfloxacin + Terbinafine
Severity: Minor
Norfloxacin and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norfloxacin inhibits CYP1A2 and may raise terbinafine levels slightly. Since terbinafine has several clearance routes, a clinically relevant effect is unlikely.
What this interaction means in plain words
Norfloxacin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Norfloxacin belongs to Anti Bacterial; Terbinafine belongs to Anti Fungals.
Why it happens
Norfloxacin inhibits CYP1A2, a minor pathway of terbinafine metabolism.
What to do
No dose adjustment is needed; be aware of possible terbinafine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Norfloxacin
- Hydrocortisone + Norfloxacin Major
- Mycophenolic acid + Norfloxacin Moderate
Frequently asked questions
Can I take Norfloxacin with Terbinafine?
MediHelp rates the interaction as minor. Norfloxacin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Norfloxacin inhibits CYP1A2 and may raise terbinafine levels slightly. Since terbinafine has several clearance routes, a clinically relevant effect is unlikely.
How serious is the interaction between Norfloxacin and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of possible terbinafine adverse effects.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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