Drug interactions
Nafcillin + Nifedipine
Severity: Moderate
Nafcillin and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and lower nifedipine concentrations, potentially reducing blood pressure or angina control. The effect may persist after nafcillin is stopped, and loss of effect may emerge over days.
What this interaction means in plain words
Nafcillin and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing the first-pass and systemic metabolism of nifedipine.
What to do
Monitor blood pressure and anginal symptoms during and after nafcillin therapy and increase the nifedipine dose if needed. Consider an alternative antibiotic if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Nafcillin with Nifedipine?
MediHelp rates the interaction as moderate. Nafcillin and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin can induce CYP3A4 and lower nifedipine concentrations, potentially reducing blood pressure or angina control. The effect may persist after nafcillin is stopped, and loss of effect may emerge over days.
How serious is the interaction between Nafcillin and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms during and after nafcillin therapy and increase the nifedipine dose if needed. Consider an alternative antibiotic if control is lost.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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