Drug interactions
Nafcillin + Nilotinib
Severity: Moderate
Nafcillin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and may reduce nilotinib concentrations. Reduced exposure may compromise antileukemic efficacy.
What this interaction means in plain words
Nafcillin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by nafcillin increasing nilotinib metabolism.
What to do
Where possible choose an alternative antibiotic that does not induce CYP3A4. If it is required, monitor for reduced response to nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nafcillin with Nilotinib?
MediHelp rates the interaction as moderate. Nafcillin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin can induce CYP3A4 and may reduce nilotinib concentrations. Reduced exposure may compromise antileukemic efficacy.
How serious is the interaction between Nafcillin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an alternative antibiotic that does not induce CYP3A4. If it is required, monitor for reduced response to nilotinib.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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