Drug interactions
Nafcillin + Pazopanib
Severity: Moderate
Nafcillin and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower pazopanib concentrations, risking reduced efficacy. The effect is documented mainly with other drugs and by case reports.
What this interaction means in plain words
Nafcillin and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing pazopanib metabolism.
What to do
Use an alternative antibiotic such as a cephalosporin if clinically appropriate. Otherwise monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Nafcillin with Pazopanib?
MediHelp rates the interaction as moderate. Nafcillin and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin induces CYP3A4 and may lower pazopanib concentrations, risking reduced efficacy. The effect is documented mainly with other drugs and by case reports.
How serious is the interaction between Nafcillin and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic such as a cephalosporin if clinically appropriate. Otherwise monitor tumor response.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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