Drug interactions
Nafcillin + Pimavanserin
Severity: Moderate
Nafcillin and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower pimavanserin concentrations. The result could be reduced control of psychosis symptoms during prolonged nafcillin therapy.
What this interaction means in plain words
Nafcillin and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, speeding pimavanserin metabolism.
What to do
Monitor for reduced pimavanserin effect during nafcillin courses and consider a dose increase if symptoms worsen. Re-evaluate the dose once nafcillin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Nafcillin with Pimavanserin?
MediHelp rates the interaction as moderate. Nafcillin and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower pimavanserin concentrations. The result could be reduced control of psychosis symptoms during prolonged nafcillin therapy.
How serious is the interaction between Nafcillin and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pimavanserin effect during nafcillin courses and consider a dose increase if symptoms worsen. Re-evaluate the dose once nafcillin is stopped.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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