Drug interactions
Nafcillin + Praziquantel
Severity: Moderate
Nafcillin and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may reduce praziquantel concentrations. Subtherapeutic exposure could compromise cure, notably in neurocysticercosis or schistosomiasis.
What this interaction means in plain words
Nafcillin and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing hepatic and intestinal metabolism of praziquantel.
What to do
Use an alternative antibiotic that does not induce CYP3A4 when feasible. Otherwise monitor clinical and parasitological response to praziquantel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Nafcillin with Praziquantel?
MediHelp rates the interaction as moderate. Nafcillin and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may reduce praziquantel concentrations. Subtherapeutic exposure could compromise cure, notably in neurocysticercosis or schistosomiasis.
How serious is the interaction between Nafcillin and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic that does not induce CYP3A4 when feasible. Otherwise monitor clinical and parasitological response to praziquantel.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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