Drug interactions
Nafcillin + Quinine
Severity: Minor
Nafcillin and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin may induce CYP3A4 and lower quinine exposure. This could reduce antimalarial efficacy, though the effect is weak and rarely documented.
What this interaction means in plain words
Nafcillin and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak induction of CYP3A4 by nafcillin increases quinine metabolism.
What to do
Monitor clinical and parasitological response when treating malaria with quinine. Consider an alternative antibiotic if treatment response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Nafcillin with Quinine?
MediHelp rates the interaction as minor. Nafcillin and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin may induce CYP3A4 and lower quinine exposure. This could reduce antimalarial efficacy, though the effect is weak and rarely documented.
How serious is the interaction between Nafcillin and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical and parasitological response when treating malaria with quinine. Consider an alternative antibiotic if treatment response is inadequate.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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