Drug interactions
Nafcillin + Sorafenib
Severity: Moderate
Nafcillin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and can lower sorafenib concentrations. This may reduce the therapeutic effect of sorafenib.
What this interaction means in plain words
Nafcillin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing sorafenib clearance.
What to do
Use an alternative antibiotic that is not an inducer where possible. If nafcillin is needed, monitor for reduced sorafenib response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Nafcillin with Sorafenib?
MediHelp rates the interaction as moderate. Nafcillin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin induces CYP3A4 and can lower sorafenib concentrations. This may reduce the therapeutic effect of sorafenib.
How serious is the interaction between Nafcillin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic that is not an inducer where possible. If nafcillin is needed, monitor for reduced sorafenib response.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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