Drug interactions
Nafcillin + Sunitinib
Severity: Moderate
Nafcillin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and may lower sunitinib and its active metabolite exposure. This could reduce antitumor efficacy.
What this interaction means in plain words
Nafcillin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing the metabolism of sunitinib.
What to do
Monitor for reduced tumor response; if an alternative antibiotic is clinically suitable, prefer one without enzyme-inducing activity. Consider sunitinib dose adjustment per labeling for CYP3A4 inducers if prolonged coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Nafcillin with Sunitinib?
MediHelp rates the interaction as moderate. Nafcillin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin can induce CYP3A4 and may lower sunitinib and its active metabolite exposure. This could reduce antitumor efficacy.
How serious is the interaction between Nafcillin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response; if an alternative antibiotic is clinically suitable, prefer one without enzyme-inducing activity. Consider sunitinib dose adjustment per labeling for CYP3A4 inducers if prolonged coadministration is needed.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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