Drug interactions
Nafcillin + Tolterodine
Severity: Minor
Nafcillin and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. For tolterodine, which is mainly metabolized by CYP2D6, the effect is expected to be small, though it may matter in poor CYP2D6 metabolizers.
What this interaction means in plain words
Nafcillin and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 induction by nafcillin increasing tolterodine metabolism.
What to do
No empirical dose change is needed. Reassess bladder symptom control during prolonged nafcillin courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nafcillin and Tolterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tolterodine
Frequently asked questions
Can I take Nafcillin with Tolterodine?
MediHelp rates the interaction as minor. Nafcillin and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is a CYP3A4 inducer and may lower exposure to CYP3A4 substrates. For tolterodine, which is mainly metabolized by CYP2D6, the effect is expected to be small, though it may matter in poor CYP2D6 metabolizers.
How serious is the interaction between Nafcillin and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Reassess bladder symptom control during prolonged nafcillin courses.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
