Drug interactions
Nafcillin + Vincristine
Severity: Moderate
Nafcillin and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and can lower exposure to CYP3A4 substrates. This could reduce vincristine exposure and effect, although the clinical impact has not been well documented.
What this interaction means in plain words
Nafcillin and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by nafcillin increasing vincristine metabolism.
What to do
Where possible choose a non-inducing antibiotic during vincristine courses. If nafcillin is required, monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Nafcillin with Vincristine?
MediHelp rates the interaction as moderate. Nafcillin and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and can lower exposure to CYP3A4 substrates. This could reduce vincristine exposure and effect, although the clinical impact has not been well documented.
How serious is the interaction between Nafcillin and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose a non-inducing antibiotic during vincristine courses. If nafcillin is required, monitor treatment response.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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