Drug interactions
Naproxen + Neomycin po
Severity: Minor
Naproxen and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can lower renal function and reduce clearance of aminoglycosides, with the best documented effect in preterm neonates given indomethacin or ibuprofen. Oral neomycin is poorly absorbed, so systemic exposure is small in most patients and a meaningful interaction with naproxen is unlikely.
What this interaction means in plain words
Naproxen and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-induced reduction in renal prostaglandin-dependent perfusion and glomerular filtration could slow clearance of any absorbed aminoglycoside.
What to do
No routine action is needed with intact gut and normal renal function. Monitor renal function if neomycin is given for a long period or with gut mucosal damage or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Naproxen with Neomycin po?
MediHelp rates the interaction as minor. Naproxen and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can lower renal function and reduce clearance of aminoglycosides, with the best documented effect in preterm neonates given indomethacin or ibuprofen. Oral neomycin is poorly absorbed, so systemic exposure is small in most patients and a meaningful interaction with naproxen is unlikely.
How serious is the interaction between Naproxen and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed with intact gut and normal renal function. Monitor renal function if neomycin is given for a long period or with gut mucosal damage or renal impairment.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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