Drug interactions
Naproxen + Olmesartan
Severity: Moderate
Naproxen and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can blunt the antihypertensive effect of olmesartan and, together with it, may impair renal function, especially in elderly or volume-depleted patients. Potassium may also rise.
What this interaction means in plain words
Naproxen and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Olmesartan belongs to Cardiovascular.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins and, combined with angiotensin receptor blockade, lower glomerular filtration pressure and impair potassium excretion.
What to do
Monitor blood pressure, serum creatinine and potassium after starting naproxen and ensure adequate hydration. Use the shortest NSAID course or an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Naproxen with Olmesartan?
MediHelp rates the interaction as moderate. Naproxen and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can blunt the antihypertensive effect of olmesartan and, together with it, may impair renal function, especially in elderly or volume-depleted patients. Potassium may also rise.
How serious is the interaction between Naproxen and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting naproxen and ensure adequate hydration. Use the shortest NSAID course or an alternative analgesic in high-risk patients.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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