Drug interactions
Naproxen + Prazosin
Severity: Minor
Naproxen and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen may reduce the blood pressure lowering effect of prazosin. The effect is usually modest.
What this interaction means in plain words
Naproxen and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naproxen belongs to Musculoskeletal; Prazosin belongs to Genitourinary.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and fluid retention oppose alpha-blocker effects.
What to do
Monitor blood pressure if naproxen is taken regularly and adjust prazosin if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Naproxen with Prazosin?
MediHelp rates the interaction as minor. Naproxen and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naproxen may reduce the blood pressure lowering effect of prazosin. The effect is usually modest.
How serious is the interaction between Naproxen and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if naproxen is taken regularly and adjust prazosin if needed.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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