Drug interactions
Naproxen + Rivastigmine
Severity: Moderate
Naproxen and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rivastigmine increases gastric acid secretion through cholinergic stimulation, and naproxen damages the gastric mucosa. Together they may raise the risk of gastrointestinal irritation, ulceration and bleeding, especially in older patients.
What this interaction means in plain words
Naproxen and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Rivastigmine belongs to Central Nervous System.
Why it happens
Additive gastric mucosal injury: NSAID prostaglandin inhibition plus cholinesterase inhibitor-induced increase in gastric acid secretion.
What to do
Monitor for dyspepsia, melena and signs of occult blood loss, using the lowest effective naproxen dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in patients at high GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Naproxen with Rivastigmine?
MediHelp rates the interaction as moderate. Naproxen and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rivastigmine increases gastric acid secretion through cholinergic stimulation, and naproxen damages the gastric mucosa. Together they may raise the risk of gastrointestinal irritation, ulceration and bleeding, especially in older patients.
How serious is the interaction between Naproxen and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dyspepsia, melena and signs of occult blood loss, using the lowest effective naproxen dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in patients at high GI risk.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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