Drug interactions
Naproxen + Telmisartan-amlodipine
Severity: Moderate
Naproxen and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can blunt the blood pressure lowering effect of telmisartan. In combination with an angiotensin receptor blocker, NSAIDs can also reduce glomerular filtration and cause acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Naproxen and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces renal perfusion and sodium excretion, opposing ARB effects and adding to the risk of renal impairment and hyperkalemia.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or stopping naproxen, and keep the NSAID course short at the lowest effective dose. Ensure adequate hydration and consider paracetamol or another alternative in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Naproxen with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Naproxen and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can blunt the blood pressure lowering effect of telmisartan. In combination with an angiotensin receptor blocker, NSAIDs can also reduce glomerular filtration and cause acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
How serious is the interaction between Naproxen and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or stopping naproxen, and keep the NSAID course short at the lowest effective dose. Ensure adequate hydration and consider paracetamol or another alternative in high-risk patients.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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