Drug interactions
Naproxen + Telmisartan
Severity: Moderate
Naproxen and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of angiotensin receptor blockers and, in volume-depleted or elderly patients, may precipitate acute kidney injury. Hyperkalemia can also occur.
What this interaction means in plain words
Naproxen and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Telmisartan belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory renal prostaglandins, reducing glomerular perfusion that is dependent on them while ARB blocks efferent arteriolar tone, impairing filtration and sodium excretion.
What to do
Maintain hydration and monitor blood pressure, serum creatinine and potassium after starting or changing naproxen. Avoid or limit NSAID use in elderly, dehydrated or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Naproxen with Telmisartan?
MediHelp rates the interaction as moderate. Naproxen and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of angiotensin receptor blockers and, in volume-depleted or elderly patients, may precipitate acute kidney injury. Hyperkalemia can also occur.
How serious is the interaction between Naproxen and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, serum creatinine and potassium after starting or changing naproxen. Avoid or limit NSAID use in elderly, dehydrated or renally impaired patients.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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