Drug interactions
Naproxen + Temocillin
Severity: Minor
Naproxen and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen and other NSAIDs compete for renal tubular secretion with penicillins and may modestly raise penicillin levels. Temocillin is renally cleared, so clinically important effects are mainly a concern in renal impairment.
What this interaction means in plain words
Naproxen and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transport may reduce penicillin clearance.
What to do
No routine adjustment is needed. Monitor renal function and adjust the temocillin dose for renal impairment as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Naproxen with Temocillin?
MediHelp rates the interaction as minor. Naproxen and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naproxen and other NSAIDs compete for renal tubular secretion with penicillins and may modestly raise penicillin levels. Temocillin is renally cleared, so clinically important effects are mainly a concern in renal impairment.
How serious is the interaction between Naproxen and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and adjust the temocillin dose for renal impairment as usual.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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