Drug interactions
Naproxen + Tenofovir df
Severity: Moderate
Naproxen and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by the kidneys and can injure proximal tubules, while NSAIDs reduce renal perfusion. Regular or high-dose NSAID use with tenofovir has been associated with acute kidney injury and may increase tenofovir exposure.
What this interaction means in plain words
Naproxen and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from NSAID prostaglandin inhibition and tenofovir tubular toxicity, with competition for renal elimination.
What to do
Prefer paracetamol or a non-NSAID alternative. If an NSAID is necessary, use the lowest dose briefly and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Naproxen and Tenofovir df, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Naproxen with Tenofovir df?
MediHelp rates the interaction as moderate. Naproxen and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by the kidneys and can injure proximal tubules, while NSAIDs reduce renal perfusion. Regular or high-dose NSAID use with tenofovir has been associated with acute kidney injury and may increase tenofovir exposure.
How serious is the interaction between Naproxen and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or a non-NSAID alternative. If an NSAID is necessary, use the lowest dose briefly and monitor serum creatinine and phosphate.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
