Drug interactions
Naproxen + Ticarcillin
Severity: Moderate
Naproxen and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs compete with penicillins for renal tubular secretion and may modestly raise penicillin levels. Ticarcillin can also impair platelet function at high doses, so bleeding risk may be additive with naproxen.
What this interaction means in plain words
Naproxen and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion plus additive platelet dysfunction from both drugs.
What to do
Monitor for bleeding and bruising, especially at high ticarcillin doses or with renal impairment. Check renal function and adjust the antibiotic dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Naproxen with Ticarcillin?
MediHelp rates the interaction as moderate. Naproxen and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs compete with penicillins for renal tubular secretion and may modestly raise penicillin levels. Ticarcillin can also impair platelet function at high doses, so bleeding risk may be additive with naproxen.
How serious is the interaction between Naproxen and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising, especially at high ticarcillin doses or with renal impairment. Check renal function and adjust the antibiotic dose accordingly.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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