Drug interactions
Naproxen + Vorapaxar
Severity: Major
Naproxen and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a PAR-1 antagonist that inhibits platelet aggregation, and naproxen also impairs platelet function and irritates the gastric mucosa. Combined use increases the risk of bleeding.
What this interaction means in plain words
Naproxen and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effects through different pathways, together with NSAID gastrointestinal mucosal injury.
What to do
Avoid regular NSAID use where possible and use paracetamol for pain. If combined, consider gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Naproxen with Vorapaxar?
MediHelp rates the interaction as major. Naproxen and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a PAR-1 antagonist that inhibits platelet aggregation, and naproxen also impairs platelet function and irritates the gastric mucosa. Combined use increases the risk of bleeding.
How serious is the interaction between Naproxen and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and use paracetamol for pain. If combined, consider gastroprotection and monitor for bleeding.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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