Drug interactions
Nateglinide + Parecoxib
Severity: Minor
Nateglinide and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both nateglinide and parecoxib's active metabolite valdecoxib involve CYP2C9, but nateglinide is not a clinically meaningful inhibitor of this enzyme. No relevant change in parecoxib exposure is expected.
What this interaction means in plain words
Nateglinide and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition for CYP2C9; no established clinically relevant inhibition by nateglinide.
What to do
No specific action is required beyond routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Parecoxib?
MediHelp rates the interaction as minor. Nateglinide and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both nateglinide and parecoxib's active metabolite valdecoxib involve CYP2C9, but nateglinide is not a clinically meaningful inhibitor of this enzyme. No relevant change in parecoxib exposure is expected.
How serious is the interaction between Nateglinide and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required beyond routine monitoring.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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