Drug interactions
Nateglinide + Phenobarbital
Severity: Moderate
Nateglinide and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a broad enzyme inducer and may increase the metabolism of nateglinide. Reduced exposure can lead to poorer glycemic control, and the effect reverses when phenobarbital is stopped.
What this interaction means in plain words
Nateglinide and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2C9 and CYP3A4 by phenobarbital increases nateglinide clearance.
What to do
Monitor blood glucose after starting or stopping phenobarbital and titrate the nateglinide dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Phenobarbital?
MediHelp rates the interaction as moderate. Nateglinide and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a broad enzyme inducer and may increase the metabolism of nateglinide. Reduced exposure can lead to poorer glycemic control, and the effect reverses when phenobarbital is stopped.
How serious is the interaction between Nateglinide and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping phenobarbital and titrate the nateglinide dose accordingly.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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