Drug interactions
Nateglinide + Sulfadiazine
Severity: Moderate
Nateglinide and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics can potentiate hypoglycemia from insulin secretagogues, and sulfadiazine may inhibit CYP2C9. Nateglinide exposure and hypoglycemia risk could rise, though clinical data are limited.
What this interaction means in plain words
Nateglinide and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP2C9 inhibition and protein binding displacement, plus intrinsic hypoglycemic effects of sulfonamides.
What to do
Monitor blood glucose during sulfadiazine therapy and lower the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Sulfadiazine?
MediHelp rates the interaction as moderate. Nateglinide and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics can potentiate hypoglycemia from insulin secretagogues, and sulfadiazine may inhibit CYP2C9. Nateglinide exposure and hypoglycemia risk could rise, though clinical data are limited.
How serious is the interaction between Nateglinide and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during sulfadiazine therapy and lower the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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