Drug interactions
Nateglinide + Sulfamethoxazole
Severity: Moderate
Nateglinide and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9 and can increase exposure to CYP2C9 substrates such as nateglinide. This may raise the risk of hypoglycemia, and sulfonamides can also have hypoglycemic effects of their own.
What this interaction means in plain words
Nateglinide and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9-mediated nateglinide metabolism, with possible protein binding displacement.
What to do
Monitor blood glucose during co-trimoxazole therapy and reduce the nateglinide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Nateglinide and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole inhibits CYP2C9 and can increase exposure to CYP2C9 substrates such as nateglinide. This may raise the risk of hypoglycemia, and sulfonamides can also have hypoglycemic effects of their own.
How serious is the interaction between Nateglinide and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-trimoxazole therapy and reduce the nateglinide dose if hypoglycemia develops.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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