Drug interactions
Nefazodone + Oxybutynin
Severity: Moderate
Nefazodone and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can increase oxybutynin concentrations, especially after oral dosing. This may intensify anticholinergic effects and sedation.
What this interaction means in plain words
Nefazodone and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated first-pass and hepatic metabolism of oxybutynin.
What to do
Monitor for anticholinergic and CNS adverse effects and lower the oxybutynin dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Frequently asked questions
Can I take Nefazodone with Oxybutynin?
MediHelp rates the interaction as moderate. Nefazodone and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and can increase oxybutynin concentrations, especially after oral dosing. This may intensify anticholinergic effects and sedation.
How serious is the interaction between Nefazodone and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic and CNS adverse effects and lower the oxybutynin dose if they occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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