Drug interactions
Nefazodone + Pazopanib
Severity: Major
Nefazodone and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may considerably raise pazopanib concentrations. This increases the chance of liver injury, hypertension and QT prolongation, and nefazodone itself is hepatotoxic.
What this interaction means in plain words
Nefazodone and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong inhibition of CYP3A4-mediated metabolism of pazopanib.
What to do
Use an alternative antidepressant with minimal CYP3A4 inhibition. If unavoidable, reduce pazopanib to 400 mg daily and monitor liver tests.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Nefazodone with Pazopanib?
MediHelp rates the interaction as major. Nefazodone and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nefazodone is a strong CYP3A4 inhibitor and may considerably raise pazopanib concentrations. This increases the chance of liver injury, hypertension and QT prolongation, and nefazodone itself is hepatotoxic.
How serious is the interaction between Nefazodone and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antidepressant with minimal CYP3A4 inhibition. If unavoidable, reduce pazopanib to 400 mg daily and monitor liver tests.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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