Drug interactions
Nefazodone + Pioglitazone
Severity: Moderate
Nefazodone and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone strongly inhibits CYP3A4 and may modestly raise pioglitazone exposure, increasing glucose lowering and fluid retention. Both drugs also carry hepatotoxicity warnings, adding to concern.
What this interaction means in plain words
Nefazodone and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reduces pioglitazone clearance, a secondary pathway to CYP2C8.
What to do
Monitor glucose, edema and liver function, and reduce the pioglitazone dose if adverse effects appear. Consider an alternative antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pioglitazone
Frequently asked questions
Can I take Nefazodone with Pioglitazone?
MediHelp rates the interaction as moderate. Nefazodone and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone strongly inhibits CYP3A4 and may modestly raise pioglitazone exposure, increasing glucose lowering and fluid retention. Both drugs also carry hepatotoxicity warnings, adding to concern.
How serious is the interaction between Nefazodone and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, edema and liver function, and reduce the pioglitazone dose if adverse effects appear. Consider an alternative antidepressant.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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