Drug interactions
Nefazodone + Praziquantel
Severity: Moderate
Nefazodone and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may increase praziquantel concentrations. This may add to dizziness and sedation, which nefazodone itself can cause.
What this interaction means in plain words
Nefazodone and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4, reducing praziquantel metabolism.
What to do
Monitor for sedation, dizziness and other praziquantel adverse effects, and advise against driving after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Nefazodone with Praziquantel?
MediHelp rates the interaction as moderate. Nefazodone and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may increase praziquantel concentrations. This may add to dizziness and sedation, which nefazodone itself can cause.
How serious is the interaction between Nefazodone and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and other praziquantel adverse effects, and advise against driving after dosing.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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