Drug interactions
Nefazodone + Rasagiline
Severity: Contraindicated
Nefazodone and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an MAO inhibitor with the serotonergic antidepressant nefazodone can cause serotonin syndrome, with agitation, hyperthermia, tremor, autonomic instability and seizures. Nefazodone labeling prohibits use with MAOIs and requires washout intervals.
What this interaction means in plain words
Nefazodone and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive increase in synaptic serotonin through MAO inhibition and nefazodone serotonin reuptake inhibition and receptor activity.
What to do
Do not co-administer; allow at least 14 days after stopping rasagiline before starting nefazodone and at least 7 days after stopping nefazodone before starting rasagiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Nefazodone with Rasagiline?
MediHelp rates the interaction as contraindicated. Nefazodone and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAO inhibitor with the serotonergic antidepressant nefazodone can cause serotonin syndrome, with agitation, hyperthermia, tremor, autonomic instability and seizures. Nefazodone labeling prohibits use with MAOIs and requires washout intervals.
How serious is the interaction between Nefazodone and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days after stopping rasagiline before starting nefazodone and at least 7 days after stopping nefazodone before starting rasagiline.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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