Drug interactions
Nefazodone + Safinamide
Severity: Contraindicated
Nefazodone and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits serotonin reuptake and blocks 5-HT2A receptors, and with MAO inhibitors there is a risk of serotonin syndrome. Safinamide labeling cautions against antidepressant combinations of this kind.
What this interaction means in plain words
Nefazodone and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Serotonin reuptake inhibition combined with reduced serotonin metabolism through MAO inhibition increases synaptic serotonin.
What to do
Avoid concurrent use and allow at least 14 days between stopping either agent and starting the other. Choose an antidepressant strategy that does not overlap with MAO inhibition.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Nefazodone with Safinamide?
MediHelp rates the interaction as contraindicated. Nefazodone and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone inhibits serotonin reuptake and blocks 5-HT2A receptors, and with MAO inhibitors there is a risk of serotonin syndrome. Safinamide labeling cautions against antidepressant combinations of this kind.
How serious is the interaction between Nefazodone and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow at least 14 days between stopping either agent and starting the other. Choose an antidepressant strategy that does not overlap with MAO inhibition.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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