Drug interactions
Nefazodone + Selegiline
Severity: Contraindicated
Nefazodone and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits serotonin reuptake and antagonizes 5-HT2A receptors, and combining it with an MAO inhibitor may lead to serotonin syndrome. Labeling for nefazodone contraindicates MAOIs.
What this interaction means in plain words
Nefazodone and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive serotonergic effects from reuptake inhibition combined with MAO inhibition.
What to do
Do not combine. Allow a washout of at least 14 days after stopping selegiline before nefazodone, and 7 days after stopping nefazodone before selegiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Nefazodone with Selegiline?
MediHelp rates the interaction as contraindicated. Nefazodone and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone inhibits serotonin reuptake and antagonizes 5-HT2A receptors, and combining it with an MAO inhibitor may lead to serotonin syndrome. Labeling for nefazodone contraindicates MAOIs.
How serious is the interaction between Nefazodone and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Allow a washout of at least 14 days after stopping selegiline before nefazodone, and 7 days after stopping nefazodone before selegiline.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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