Drug interactions
Nefazodone + Sorafenib
Severity: Moderate
Nefazodone and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone strongly inhibits CYP3A4 and may increase sorafenib exposure. Higher levels could worsen dose-related adverse effects.
What this interaction means in plain words
Nefazodone and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4, reducing sorafenib metabolism.
What to do
Monitor for sorafenib toxicity such as hypertension, diarrhea and skin reactions. Consider an alternative antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Nefazodone with Sorafenib?
MediHelp rates the interaction as moderate. Nefazodone and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone strongly inhibits CYP3A4 and may increase sorafenib exposure. Higher levels could worsen dose-related adverse effects.
How serious is the interaction between Nefazodone and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity such as hypertension, diarrhea and skin reactions. Consider an alternative antidepressant.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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