Drug interactions
Nefazodone + Tamoxifen
Severity: Moderate
Nefazodone and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may change tamoxifen metabolism. Both drugs carry some QT and hepatotoxicity concerns, so combined use adds risk.
What this interaction means in plain words
Nefazodone and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition alters tamoxifen N-demethylation, with overlapping hepatic and QT risks.
What to do
Prefer a different antidepressant such as an SSRI with minimal CYP2D6 inhibition, for example citalopram or venlafaxine. Monitor liver tests if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Nefazodone with Tamoxifen?
MediHelp rates the interaction as moderate. Nefazodone and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may change tamoxifen metabolism. Both drugs carry some QT and hepatotoxicity concerns, so combined use adds risk.
How serious is the interaction between Nefazodone and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different antidepressant such as an SSRI with minimal CYP2D6 inhibition, for example citalopram or venlafaxine. Monitor liver tests if both are used.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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