Drug interactions
Nefazodone + Tobramycin
Severity: Minor
Nefazodone and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone may inhibit P-glycoprotein in vitro, but tobramycin is cleared by glomerular filtration and is not a clinically important P-glycoprotein substrate. A meaningful increase in tobramycin levels has not been shown.
What this interaction means in plain words
Nefazodone and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical P-glycoprotein inhibition; clinical relevance is not established.
What to do
No specific action is needed beyond routine tobramycin level and renal monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Nefazodone with Tobramycin?
MediHelp rates the interaction as minor. Nefazodone and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone may inhibit P-glycoprotein in vitro, but tobramycin is cleared by glomerular filtration and is not a clinically important P-glycoprotein substrate. A meaningful increase in tobramycin levels has not been shown.
How serious is the interaction between Nefazodone and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine tobramycin level and renal monitoring.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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