Drug interactions
Nefazodone + Tolmetin
Severity: Moderate
Nefazodone and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity that may affect platelet function, and NSAIDs inhibit platelets and injure gastric mucosa. The combination may raise the risk of bleeding, especially upper gastrointestinal bleeding, although nefazodone's serotonin reuptake effect is relatively weak.
What this interaction means in plain words
Nefazodone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function (serotonin reuptake inhibition plus COX inhibition) with NSAID mucosal injury.
What to do
Watch for signs of gastrointestinal bleeding and consider gastroprotection in at-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Nefazodone with Tolmetin?
MediHelp rates the interaction as moderate. Nefazodone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity that may affect platelet function, and NSAIDs inhibit platelets and injure gastric mucosa. The combination may raise the risk of bleeding, especially upper gastrointestinal bleeding, although nefazodone's serotonin reuptake effect is relatively weak.
How serious is the interaction between Nefazodone and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of gastrointestinal bleeding and consider gastroprotection in at-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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