Drug interactions
Nefazodone + Vinorelbine
Severity: Major
Nefazodone and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can raise vinorelbine concentrations. This may enhance myelosuppression, neuropathy and constipation.
What this interaction means in plain words
Nefazodone and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nefazodone inhibits CYP3A4-mediated vinorelbine metabolism.
What to do
Avoid the combination and choose an antidepressant with less CYP3A4 inhibition, such as sertraline. If unavoidable, monitor neutrophil counts and neurotoxicity and reduce the vinorelbine dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Nefazodone with Vinorelbine?
MediHelp rates the interaction as major. Nefazodone and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nefazodone is a strong CYP3A4 inhibitor and can raise vinorelbine concentrations. This may enhance myelosuppression, neuropathy and constipation.
How serious is the interaction between Nefazodone and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antidepressant with less CYP3A4 inhibition, such as sertraline. If unavoidable, monitor neutrophil counts and neurotoxicity and reduce the vinorelbine dose as needed.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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