Drug interactions
Nelfinavir + Pitavastatin
Severity: Moderate
Nelfinavir and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir may inhibit OATP1B1 and raise pitavastatin concentrations. This could increase the risk of myopathy, though pitavastatin has little CYP3A4 involvement.
What this interaction means in plain words
Nelfinavir and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Pitavastatin belongs to Cardiovascular.
Why it happens
Nelfinavir may inhibit OATP1B1-mediated hepatic uptake of pitavastatin.
What to do
Monitor for muscle symptoms and check CK if they occur. Use the lowest effective pitavastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Pitavastatin?
MediHelp rates the interaction as moderate. Nelfinavir and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir may inhibit OATP1B1 and raise pitavastatin concentrations. This could increase the risk of myopathy, though pitavastatin has little CYP3A4 involvement.
How serious is the interaction between Nelfinavir and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and check CK if they occur. Use the lowest effective pitavastatin dose.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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