Drug interactions
Nelfinavir + Tenofovir disoproxil
Severity: Minor
Nelfinavir and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are used in combination antiretroviral regimens, in which immune reconstitution inflammatory syndrome can occur after therapy begins. This reflects the effect of ART in general rather than a specific interaction between the two drugs.
What this interaction means in plain words
Nelfinavir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No specific interaction mechanism; immune reconstitution is a general consequence of effective ART.
What to do
No adjustment is needed; monitor for new inflammatory symptoms of opportunistic infections in the first weeks to months of therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Nelfinavir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are used in combination antiretroviral regimens, in which immune reconstitution inflammatory syndrome can occur after therapy begins. This reflects the effect of ART in general rather than a specific interaction between the two drugs.
How serious is the interaction between Nelfinavir and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor for new inflammatory symptoms of opportunistic infections in the first weeks to months of therapy.
What other medicines interact with Nelfinavir?
MediHelp also lists interactions of Nelfinavir with, for example, Alfuzosin, Avanafil, Dronedarone. The full list is on the Nelfinavir page.
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