Drug interactions
Nelfinavir + Ulipristal
Severity: Moderate
Nelfinavir and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may raise ulipristal concentrations. The consequences of increased exposure are not well defined.
What this interaction means in plain words
Nelfinavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nelfinavir inhibits CYP3A4-mediated ulipristal metabolism.
What to do
Consider a copper IUD or alternative emergency contraceptive. If ulipristal is used, counsel on potential adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Ulipristal?
MediHelp rates the interaction as moderate. Nelfinavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and may raise ulipristal concentrations. The consequences of increased exposure are not well defined.
How serious is the interaction between Nelfinavir and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a copper IUD or alternative emergency contraceptive. If ulipristal is used, counsel on potential adverse effects.
What other medicines interact with Nelfinavir?
MediHelp also lists interactions of Nelfinavir with, for example, Alfuzosin, Avanafil, Dronedarone. The full list is on the Nelfinavir page.
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