Drug interactions
Neomycin po + Nilotinib
Severity: Minor
Neomycin po and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so P-glycoprotein inhibition by nilotinib is unlikely to produce meaningful systemic exposure. Any clinical consequence is expected to be negligible.
What this interaction means in plain words
Neomycin po and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical P-glycoprotein inhibition by nilotinib increasing neomycin absorption.
What to do
No action is needed in most patients. Monitor renal function in those with impaired renal function or prolonged neomycin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Neomycin po with Nilotinib?
MediHelp rates the interaction as minor. Neomycin po and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so P-glycoprotein inhibition by nilotinib is unlikely to produce meaningful systemic exposure. Any clinical consequence is expected to be negligible.
How serious is the interaction between Neomycin po and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed in most patients. Monitor renal function in those with impaired renal function or prolonged neomycin use.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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