Drug interactions
Neomycin po + Rocuronium
Severity: Moderate
Neomycin po and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed but some systemic uptake can occur, particularly with inflamed bowel or renal impairment. Aminoglycosides can potentiate non-depolarizing blockers, causing prolonged paralysis or apnea.
What this interaction means in plain words
Neomycin po and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aminoglycoside-induced reduction of presynaptic acetylcholine release and postsynaptic sensitivity, adding to rocuronium blockade.
What to do
Monitor neuromuscular function with train-of-four and titrate rocuronium to effect, especially in renal impairment or bowel disease. Have ventilatory support available and delay extubation until full recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Frequently asked questions
Can I take Neomycin po with Rocuronium?
MediHelp rates the interaction as moderate. Neomycin po and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin is poorly absorbed but some systemic uptake can occur, particularly with inflamed bowel or renal impairment. Aminoglycosides can potentiate non-depolarizing blockers, causing prolonged paralysis or apnea.
How serious is the interaction between Neomycin po and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and titrate rocuronium to effect, especially in renal impairment or bowel disease. Have ventilatory support available and delay extubation until full recovery.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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