Drug interactions
Neomycin po + Sorafenib
Severity: Moderate
Neomycin po and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin given for a short course reduced sorafenib exposure in healthy volunteers. This may lessen sorafenib efficacy during neomycin use.
What this interaction means in plain words
Neomycin po and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probably altered gut bacteria affecting enterohepatic recycling of sorafenib glucuronide; not firmly established.
What to do
Avoid prolonged oral neomycin with sorafenib when possible. If needed, monitor for reduced response to sorafenib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Neomycin po and Sorafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sorafenib
Frequently asked questions
Can I take Neomycin po with Sorafenib?
MediHelp rates the interaction as moderate. Neomycin po and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin given for a short course reduced sorafenib exposure in healthy volunteers. This may lessen sorafenib efficacy during neomycin use.
How serious is the interaction between Neomycin po and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged oral neomycin with sorafenib when possible. If needed, monitor for reduced response to sorafenib.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
