Drug interactions
Neomycin po + Tolmetin
Severity: Minor
Neomycin po and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic exposure is minimal in most patients. NSAID-related reduction in renal clearance of absorbed aminoglycoside has been described mainly in preterm infants.
What this interaction means in plain words
Neomycin po and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-induced reduction in renal clearance of absorbed aminoglycoside.
What to do
No action is needed in most adults; in neonates or renal impairment, monitor renal function and aminoglycoside exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Neomycin po with Tolmetin?
MediHelp rates the interaction as minor. Neomycin po and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so systemic exposure is minimal in most patients. NSAID-related reduction in renal clearance of absorbed aminoglycoside has been described mainly in preterm infants.
How serious is the interaction between Neomycin po and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed in most adults; in neonates or renal impairment, monitor renal function and aminoglycoside exposure.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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