Drug interactions
Neomycin po + Vitamin B12
Severity: Moderate
Neomycin po and Vitamin B12: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin can reduce absorption of oral vitamin B12, and prolonged use may contribute to B12 deficiency. The effect is more relevant with extended courses.
What this interaction means in plain words
Neomycin po and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Neomycin causes mucosal injury and binds bile acids, impairing intestinal B12 uptake.
What to do
Monitor B12 status with prolonged neomycin therapy. Use parenteral B12 if deficiency develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin B12
Frequently asked questions
Can I take Neomycin po with Vitamin B12?
MediHelp rates the interaction as moderate. Neomycin po and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin can reduce absorption of oral vitamin B12, and prolonged use may contribute to B12 deficiency. The effect is more relevant with extended courses.
How serious is the interaction between Neomycin po and Vitamin B12?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor B12 status with prolonged neomycin therapy. Use parenteral B12 if deficiency develops.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Chloramphenicol, Dichlorphenamide, Metformin. The full list is on the Vitamin B12 page.
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