Drug interactions
Nerandomilast + Pirfenidone
Severity: Moderate
Nerandomilast and Pirfenidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirfenidone lowers nerandomilast exposure, so the lower nerandomilast dose may not be effective when used with pirfenidone.
What this interaction means in plain words
Nerandomilast and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nerandomilast belongs to Miscellaneous; Pirfenidone belongs to Miscellaneous.
Why it happens
Pirfenidone reduces nerandomilast exposure, probably through enzyme induction, although the exact mechanism is uncertain.
What to do
Use the higher labeled nerandomilast dose of 18 mg twice daily when it is combined with pirfenidone. Monitor tolerability and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Frequently asked questions
Can I take Nerandomilast with Pirfenidone?
MediHelp rates the interaction as moderate. Nerandomilast and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pirfenidone lowers nerandomilast exposure, so the lower nerandomilast dose may not be effective when used with pirfenidone.
How serious is the interaction between Nerandomilast and Pirfenidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the higher labeled nerandomilast dose of 18 mg twice daily when it is combined with pirfenidone. Monitor tolerability and clinical response.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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