Drug interactions
Nesiritide + Ramipril
Severity: Moderate
Nesiritide and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nesiritide is a potent vasodilator that frequently causes hypotension, and ramipril adds to this effect. Symptomatic hypotension may limit treatment and affect renal perfusion.
What this interaction means in plain words
Nesiritide and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering through pharmacodynamic synergism.
What to do
Monitor blood pressure continuously during nesiritide infusion and reduce or stop the infusion if hypotension occurs. Review the ramipril dose if hypotension persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Nesiritide with Ramipril?
MediHelp rates the interaction as moderate. Nesiritide and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nesiritide is a potent vasodilator that frequently causes hypotension, and ramipril adds to this effect. Symptomatic hypotension may limit treatment and affect renal perfusion.
How serious is the interaction between Nesiritide and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during nesiritide infusion and reduce or stop the infusion if hypotension occurs. Review the ramipril dose if hypotension persists.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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