Drug interactions
Nesiritide + Trandolapril
Severity: Moderate
Nesiritide and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nesiritide is a potent vasodilator and hypotension is its main adverse effect. Adding trandolapril may increase the risk and degree of hypotension.
What this interaction means in plain words
Nesiritide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory and hypotensive effects.
What to do
Monitor blood pressure closely during nesiritide infusion. Reduce or stop the infusion if symptomatic hypotension occurs, and review the need for the ACE inhibitor dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Nesiritide with Trandolapril?
MediHelp rates the interaction as moderate. Nesiritide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nesiritide is a potent vasodilator and hypotension is its main adverse effect. Adding trandolapril may increase the risk and degree of hypotension.
How serious is the interaction between Nesiritide and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during nesiritide infusion. Reduce or stop the infusion if symptomatic hypotension occurs, and review the need for the ACE inhibitor dose.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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